2018英特爾ISEF學(xué)科最佳作品摘要：轉(zhuǎn)譯醫(yī)學(xué) Best of Category Abstract: Translational Medical Science

獲獎作品基本信息

年份	2018
學(xué)科	轉(zhuǎn)譯醫(yī)學(xué) Translational Medical Science
學(xué)校	Cherry Creek High School
國家/州	CO，United States of America

獲獎作品名稱

Bruxism: A Novel Diagnostic Approach

獲獎作品摘要

Bruxism, the involuntary grinding and/or clenching of teeth, is a condition which often goes undiagnosed until irreversible damage occurs. Although research on this topic has been extensive, there is still no objective diagnostic method for bruxism. Current diagnostic methods, based on clinical examination and patient history, are frequently inaccurate. Previous research has identified masticatory muscles as the main generators of human bite force. With the aid of an original device (a novel bite force recorder) which I designed, this study aimed to explore the existence of a correlation between individuals’ maximum bite force (MBF) values and bruxism. My results showed that MBF values recorded for bruxers (experimental group) were significantly higher than those for non-bruxers (control). Since occlusal guards help masticatory muscles relax and lose their hyperactive status, splint therapy is the standard procedure for treating bruxism. After four weeks of splint therapy, the MBF values recorded for bruxers displayed a significant decrease, while there was no statistically significant change for non-bruxers. These findings support my hypothesis that increased MBF values could be an indication of bruxism and could provide useful data for evaluation of jaw muscle function and activity. Measuring individuals’ MBF values could be instrumental in diagnosing bruxism. With bruxism being on the rise, additional research is required to further develop more efficient and more cost-effective methods to diagnose this condition.

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高中生科研 英特爾 Intel ISEF
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高中生科研學(xué)術(shù)活動 英特爾 Intel ISEF 簡介

英特爾國際科學(xué)與工程大獎賽，簡稱 "ISEF"，由美國 Society for Science and the Public（科學(xué)和公共服務(wù)協(xié)會）主辦，英特爾公司冠名贊助，是全球規(guī)模最大、等級最高的中學(xué)生的科研科創(chuàng)賽事。ISEF 的學(xué)術(shù)活動學(xué)科包括了所有數(shù)學(xué)、自然科學(xué)、工程的全部領(lǐng)域和部分社會科學(xué)。ISEF 素有全球青少年科學(xué)學(xué)術(shù)活動的“世界杯”之美譽(yù)，旨在鼓勵學(xué)生團(tuán)隊(duì)協(xié)作，開拓創(chuàng)新，長期專一深入地研究自己感興趣的課題。

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學(xué)科簡介：轉(zhuǎn)譯醫(yī)學(xué) Translational Medical Science

Projects that aim to improve human health and longevity by translating novel discoveries in the biomedical sciences into effective activities and tools for clinical and public health use. Bi-directional in concept, projects can be those developed through basic research moving toward clinical testing (bench-to-bedside) or projects that provide feedback about the applications of new treatments and how they can be improved (beside-to-bench).

Subcategories:

Disease Detection and Diagnosis (DIS):?Studies in this category encompass a variety of novel assay methods to promote the identification, detection and determination of disorders and disease. They may involve studies at the system, organ, or cellular levels.

Disease Prevention?(PRE):?The study of health promotion and disease prevention activities and research to improve public health. These ?studies might involve research to protect individuals from actual or potential health threats and their harmful consequences, or they may address novel approaches to aid in compliance for avoiding known health risks (e.g., smoking, drug use, obesity).

Disease Treatment and Therapies?(TRE):?The use of pharmaceuticals and other therapies, including natural and holistic remedies, intended to improve symptoms and treat or cure disorders or disease.

Drug Identification and Testing (DRU):?These studies would be conducted to identify potential drugs or extracts that could be used to treat or cure disorders or disease. Studies in this category would involve initial testing of the compounds against an intended target. This category could also include testing a range of different compounds or extracts to determine relative potency and efficacy.

Pre-Clinical Studies?(PCS):?These studies of potential drugs or therapies would include testing the intervention in platforms such as cultured cells or animal models of disease. The investigations could be directed toward determining factors such as potential drug permeability, efficacy and/or toxicity. These studies could also investigate the best route of drug administration.

Other?(OTH):?Studies that cannot be assigned to one of the above subcategories.?If the project involves multiple subcategories, the principal subcategory should be chosen instead of Other.